
HIV-1 integrase inhibitor 8
CAS No. 1568-80-5
HIV-1 integrase inhibitor 8( —— )
Catalog No. M35466 CAS No. 1568-80-5
HIV-1 integrase inhibitor 8 is an inhibitor of HIV-1 integrase, a critical enzyme necessary for the integration step in HIV replication .
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
100MG | 36 | In Stock |
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200MG | 50 | In Stock |
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500MG | 83 | In Stock |
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1G | 120 | In Stock |
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Biological Information
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Product NameHIV-1 integrase inhibitor 8
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NoteResearch use only, not for human use.
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Brief DescriptionHIV-1 integrase inhibitor 8 is an inhibitor of HIV-1 integrase, a critical enzyme necessary for the integration step in HIV replication .
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DescriptionHIV-1 integrase inhibitor 8 is a HIV-1 integrase inhibitor, compound 8.
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In VitroHIV-1 integrase inhibitor 8 is against 3′-processing (TC) and strand-transfer (ST) activities in the presence of Mn2+ as the cationic cofactor by gel assay with IC50 values of 275 μM and 200 μM, respectively. It inhibits the strand-transfer (ST) activity with an IC50 value of 200 μM.The DNA relaxation activity of MCV topoisomerase is monitored by gel electrophoresis, while DNA cleavage and religation activities were monitored using a microtiter assay. HIV-1 integrase inhibitor 8 inhibits MCV topoisomerase and DNA religation with IC50 values of 500 μM and 200 μM, respectively. This result demonstrates that compound 8 is inactive against topoisomerase in both assays. HIV-1 integrase inhibitor 8 induces cell cytotoxicity and yields a LD50 (dose at which the signal is reduced 50% due to cell death) of 20 μM in HeLa cells.
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In Vivo——
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Synonyms——
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PathwayMicrobiology/Virology
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TargetHIV
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RecptorHIV Protease
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Research Area——
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Indication——
Chemical Information
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CAS Number1568-80-5
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Formula Weight308.41
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Molecular FormulaC21H24O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (405.30 mM; Ultrasonic )
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SMILESCC1(C)CC2(CC(C)(C)c3ccc(O)cc23)c2cc(O)ccc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Molteni, et al. A New Class of HIV-1 Integrase Inhibitors: The 3,3,3', 3'-tetramethyl-1,1'-spirobi(indan)-5,5',6,6'-tetrol Family.J Med Chem?
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