HIV-1 integrase inhibitor 8

CAS No. 1568-80-5

HIV-1 integrase inhibitor 8( —— )

Catalog No. M35466 CAS No. 1568-80-5

HIV-1 integrase inhibitor 8 is an inhibitor of HIV-1 integrase, a critical enzyme necessary for the integration step in HIV replication .

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
100MG 36 In Stock
200MG 50 In Stock
500MG 83 In Stock
1G 120 In Stock

Biological Information

  • Product Name
    HIV-1 integrase inhibitor 8
  • Note
    Research use only, not for human use.
  • Brief Description
    HIV-1 integrase inhibitor 8 is an inhibitor of HIV-1 integrase, a critical enzyme necessary for the integration step in HIV replication .
  • Description
    HIV-1 integrase inhibitor 8 is a HIV-1 integrase inhibitor, compound 8.
  • In Vitro
    HIV-1 integrase inhibitor 8 is against 3′-processing (TC) and strand-transfer (ST) activities in the presence of Mn2+ as the cationic cofactor by gel assay with IC50 values of 275 μM and 200 μM, respectively. It inhibits the strand-transfer (ST) activity with an IC50 value of 200 μM.The DNA relaxation activity of MCV topoisomerase is monitored by gel electrophoresis, while DNA cleavage and religation activities were monitored using a microtiter assay. HIV-1 integrase inhibitor 8 inhibits MCV topoisomerase and DNA religation with IC50 values of 500 μM and 200 μM, respectively. This result demonstrates that compound 8 is inactive against topoisomerase in both assays. HIV-1 integrase inhibitor 8 induces cell cytotoxicity and yields a LD50 (dose at which the signal is reduced 50% due to cell death) of 20 μM in HeLa cells.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIV Protease
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1568-80-5
  • Formula Weight
    308.41
  • Molecular Formula
    C21H24O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (405.30 mM; Ultrasonic )
  • SMILES
    CC1(C)CC2(CC(C)(C)c3ccc(O)cc23)c2cc(O)ccc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Molteni, et al. A New Class of HIV-1 Integrase Inhibitors: The 3,3,3', 3'-tetramethyl-1,1'-spirobi(indan)-5,5',6,6'-tetrol Family.J Med Chem?
molnova catalog
related products
  • PF-3450074

    PF-3450074 (PF74) is a small molecule HIV capsid protein, destabilized the viral capsid in vitro; acts at an early stage of HIV-1 infection and inhibits reverse transcription in target cells.

  • Apelin-36 (rat, mous...

    Endogenous APJ receptor agonist that is secreted by adipocytes. Binds with high affinity to APJ receptors (IC50 = 5.4 nM) and potently inhibits cAMP production in vitro (EC50 = 0.52 nM). Involved in regulation of cardiovascular function, fluid homeostasis and feeding. Blocks entry of some HIV-1 and HIV-2 strains into NP-2/CD4 cells expressing APJ.

  • D77

    A potent inhibitor of HIV-1 integrase-LEDGF/p75 interaction; binds to IN and IN(T125A) with Kd of 5.81 and 15.2 uM.